Applications of Exosomes in Regenerative Medicine
In recent years, the application of exosomes in regenerative medicine has been growing. Also, many more potential applications of exosomes in regenerative medicine are still being studied.
In this article, you’ll learn the functions of exosomes and up-to-date applications of exosomes in regenerative medicine.
What are exosomes?
Exosomes are tiny vesicles that play a crucial role in cell to cell communication. Every cell in our body produces exosomes, to give information to the neighboring cells or long-distance cells, to change their behavior or to simply share information.
They transfer genetic information, proteins, and receptors, and they are capable of changing the behavior of one cell to the other. They have the ability to increase cell replication and other substances crucial for tissue regeneration.
Functions of exosomes
The major function of exosomes is to improve intercellular communication by releasing effectors and signaling molecules between cells.
Every cell in our body produces exosomes, to give information to the neighboring cells, or long distance cells, to change their behavior or to simply share information.
They transfer genetic information, proteins, and receptors, and are capable of changing the behavior of one cell to the other. They can increase cell replication and other substances crucial for tissue regeneration.
Exosomes affect all aspects of cell biology and are useful for improving intercellular communication.
Various applications of exosomes in regenerative medicine.
Exosomes have various clinical applications due to their high potency, reduced immunogenicity, and ability to cross physiological barriers such as the blood-brain barrier.
In regenerative medicine, exosomes can be used in a point of care environment for a lot of aesthetic and therapeutic purposes.
The Use of Exosomes in Hair therapy
Exosomes can be used in the early stages of hair loss to re-grow and regenerate hair.
The good thing about using exosomes for hair loss is that they can be used in both men and women.
Exosomes can help stimulate hair growth and prevent hair loss. Clinical results have also shown the efficacy of exosomes in alopecia areata.
Exosomes from follicular stem cells are said to inhibit hair loss and promote hair growth.
In the earlier stages of hair loss, hair can be regrown and regenerated in men and women by administering exosomes and growth factors.
After the first round of exosome therapy, noticeable change can be seen in 2 or 3 months but the most significant changes start from 6 to 12 months.
The Use of Exosomes in Skin-Regeneration
There are so many research and clinical trials surrounding the application of exosomes in skin treatment.
The benefits of exosome therapy in skin regeneration because of their ability to directly stimulate target cells, non-immune rejection and high stability.
These are some of the abilities of exosomes in skin regeneration:
- Regulation of inflammation
- Synthesis of collagen
- Angiogenic effect
The Anti-aging effect of exosomes
Exosomes can be used to restore aging tissues of the body due to their outstanding regenerative ability.
Signs of aging manifest due to the skin’s inability to regenerate itself, exosomes can help to maintain the skin’s elasticity and strength.
Exosome therapy is changing the approach to anti-aging treatment. The rejuvenation capability of exosomes is a great way to make your patients feel young again.
It revitalizes senescent cells by repairing damage due to aging.
With exosomes, you are improving longevity by reversing the cells that are dying due to aging.
Exosomes in Pain management
Exosome therapy can be used to relieve pain by subduing pain signals, reducing inflammation and repairing damaged tissues.
The application of Exosome in inflammatory conditions.
Exosomes can decrease inflammation, regenerate cells and modulate the immune system.
Osteoarthritis: MSC-derived exosomes can reduce the joint inflammation in osteoarthritis and also stimulates cartilage regeneration and the repair of damaged tissues.
Tendinitis: Tendinitis is the inflammation of tendons. Exosomes can reduce the inflammation associated with tendinitis and repair torn tendons and muscles.
Due to the potency of exosomes and its paracrine effect, the potential capabilities of exosomes are still being discovered and studied.
At Cellgenic, we prepare easy to transport and administer Lyophilized exosomes, suitable for use in regenerative medicine.
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How Cellgenic MSCs Revolutionize Regenerative Medicine
Stem Cells are revolutionizing the field of regenerative medicine, due to their intelligence. Once administered into the patient, they are able to identify and target areas of disease and damage. Adimarket’s Mesenchymal Stem Cell Product excretes growth factors, cytokines, and proteins, which all play a key role in the regeneration of tissue. Their anti-inflammatory and immunomodulatory properties mean that it is difficult for them to be rejected by the body. Additionally, they increase blood flow to the vital organs which need it the most.
Many proprietors of MSC products will claim that it is not necessarily important to have a high ratio of viable cells. They claim that it does not matter how many cells are ‘not viable’, or dead, so long as there is a high enough number of viable cells– however, current research has shown that this is not the case. These dead cells are detectable by the immune system, and it is believed that they can create an inflammatory response within the body at the treatment area, which would lower the effectiveness of the regenerative medicine treatments.
This bending of the science is harmful to our industry, which is why knowledgeable purveyors put one thing above all else– consistency. Our cellular concentrations are the same throughout each batch, and we make sure that there is a high ratio of viable cells. All of our samples are independently verified by a third party laboratory, and have been selected for their phenotypic and genotypic profile, characterized for optimum growth and stability. When the proper care is taken, Mesenchymal Stem Cell products have been identified as having the highest output of growth factors and stem cell factors among the current standards of care– as well as properties of angiogenesis, immunomodulation, and the potential for endogenous repair.
Cellgenic has been working for over a decade, constantly reinventing itself and reinforcing the products that we offer with the latest advancements in the field of regenerative medicine. We take every painstaking measure possible to ensure that the cellular samples that our customers use to treat their patients are second to none– this includes the consistent concentrations of our sample, which are the same throughout ensuring that every patient gets the same treatment. We offer the product in 10 million or 30 million live total nucleated cells, where other fabricators would have the same number of total cells. We ensure that every single product that we send out has been tested for low amounts of annexin, which is a cellular protein which serves as a marker for cell death.
All our Mesenchymal Stem Cell products come in 1cc vials cryogenically preserved– they are shipped overnight within the United States, conveniently delivered to your door in the morning. For use, the product is passively thawed between the palms of your hands– and ready to use when your patients are. MSC 10 contains 10 million live cells and is recommended for a single joint, or a small area. However, the MSC pure pro has 30 million live cells,and can be used for larger applications, or for up to three joints in the same patient at the same time.
If you are interested in finding out more about Cellgenic MSCs, you can send an eMail to info@stemcellsgroup.com
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Implications of Exosomes
As the newest field to regenerative medicine, it’s often exosomes therapy the least understood by those doctors newer to the field. While still not in use by many doctors, this is simply because it is new to the field. This is because many scientists are practically rabid to harnessthe benefits of this new treatment and apply them to target many of the conditions that modern medicine has allowed to slip through the cracks.
Extracellular Vesicles and Exosomes
The discovery of extracellular vesicles (EV), small bubbles composed of protein freely among cells, has been considered one of the greatest advancements in the field of medicine. They are broadly defined as something that exists outside of the cells of the human body, and they can be quite unique. Among these are exosomes, which has shown almost miraculous promise in treating inflammation, immunomodulation, cell-cell communication, and much more. Although it is certainly not a cure-all, it has been found to be good at what it does, which is almost a little bit of everything.This includes the communication and rejuvenation of all cells in the body, despite not actually being one itself.
Exosomes are created by growing a healthy stem cell culture and disposing of the cells themselves– this leaves behind the exosomes, millions of them, that were created in the process. Due to their microscopic size, what is left behind must be ultra-centrifuged, as it is the only way to concentrate them enough to use them on a patient. Despite all of their abilities, the makeup of exosomes is really quite simple, amino acids and RNA– this means that, aside from bearing immunomodulatory properties, it can also be applied to a patient without causing an immune system reaction. This is a worry that modern physicians must constantly think about when implanting foreign objects into patients, that is one of the great benefits of the use of exosome therapy.
An Overview on Exosome Therapy
Generally defined, exosome therapy is the use of exosomes in a clinical setting, a new step forward that is being happily taken by physicians worldwide. Exosome Therapy has very rapidly become one of the most popular fields of regenerative medicine treatment around the world. Painstaking research has managed to highlight the practical uses of exosomes, and how they can be used to treat conditions including lyme disease, hair loss, and arthritis. This is because, while stem cells are largely responsible for the rejuvenation of older cells, they might not be able to supply the information required for healing to take place– and this is where exosomes come in.
Consider exosomes the traffic conductors of regenerative medicine. They stimulate attention to damaged areas and work to control inflammation. In fact, many talented researchers believe that, by supporting the function of exosomes in the body, a better outcome could be obtained in patients. These scientific breakthroughs have fundamentally changed the healing process as we know it.
Exosome therapy is minimally invasive, and most commonly used in patients that present with orthopedic injuries, but this is not it’s only use. It shows great applications for anti-aging medicine, and the treatment of inflammatory and degenerative diseases. Exosome treatments generally contain a combination of growth factors, messenger RNA, micro RNA, and cytokines. The resulting exosome treatment is used in conjunction with stem cell therapies to boost the healing process in patients. These exosome therapies can be administered directly into the affected area, but they can also be administered through IV drip for those that are looking to make use of the anti-aging properties of exosomes.
Exosome injections are administered like other cellular therapies– administered directly into the part of the body affected by disease. In each case, patient dosing varies on condition and treatment plan, which means that there is no exact treatment protocol for exosome therapy. However, this allows physicians to fully customize them to a patient’s needs.
What can Exosomes Treat?
As the field of regenerative medicine constantly grows, more and more treatments are discovered every month! However, researchers have been able to offer exosomes as an exciting alternative for a wide variety of illnesses, including in arthritis therapy– it is believed to play a large role in bone and cartilage remodeling.Exosome therapy currently shows promise in treating the following conditions:
Hair Loss: Exosomes can be used to regrow hair due to their growth factor content. When injected exosomes trigger healing and the natural regeneration of hair follicles.
Lyme Disease: Exosomes may be beneficial to patients who suffer from Lyme disease, which is a very complex disease that compromises the immune system. Because it results in an increase in inflammatory responses, incorporating exosomes into one’s treatment plan could help break the cycle of inflammatory response.
Arthritis: Arthritis is known by many as the inflammation of the joints as a result of an autoimmune deficiency. Although various types of treatment are available to alleviate symptoms, nothing has been confirmed to reverse the disease’s progression.
Anti-Aging: Generally, aging can be thought of as a slow, steady inflammation of the body. Researchers have found a direct correlation between the number and types of exosomes within the body and the effects of aging, which means that exosome therapy could be used to reduce swelling in patients, and can be used to treat conditions such as crow’s feet, puffy eyes, and other markers of aging.
Pain Management: On a similar vein, many pain symptoms are also the result of inflammation– this is why certain over-the-counter medications allow for the treating of light pain. But for severe, chronic conditions that cannot be treated with over the counter options, exosome therapy could be the key to increasing their quality of life. By targeting the pained area at the source of inflammation, exosome therapy can increase quality of movement and reduce pain in certain orthopedic conditions including stress injuries.
As physicians around the world continue to study and apply exosomes, Global Stem Cells Group recognizes the fervent need to get these products into doctor’s hands. Our Cellgenic line has been in operation for years, helping physicians treat these conditions and more with exosome therapy.
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GCell: The Newest All-In-One Solution in Regenerative Medicine
Are you a physician that is currently utilizing adipose tissue, but is growing tired of the time-consuming, arduous procedure? Are you having problems finding reagents that allow you to isolate stem cells? If so, GCell might be the solution for you.
What is GCell?
GCell is a revolutionary new machine that holds the potential to become the future of adipose stem cell processing. This is due to a variety of reasons, from the compactness of the unit, to its short processing time– it truly is a valuable implement in any regenerative medicine practitioner’s office. GCell employs a process of mechanical breakdown, which in addition to shortening the duration of the treatment, also serves to keep it within legal minimal-manipulation regulations.
How Does GCell Work?
Through a system of extremely small blades and filters, it is able to homogenize a sample of fat taken from anywhere in the body, making it into a slurry of growth factors, proteins, and the other components that make up the sample. The GCell then filters out the stromal vascular fraction cells, and uses a process called photoactivation to increase their vitality. Once the process is over, the end result is a final product that can be administered to patients within forty minutes from the sample’s harvesting. This is a far cry from the previous, muti-hour long treatments that physicians have grown accustomed to, and this shortened timespan is something that both doctors and their patients will greatly appreciate.
Why GCell?
Additionally, it is a single-session treatment. This means that patients that wish to receive a GCell treatment will only have to visit their clinic once, and will not have to undergo any followup treatments. This machine provides the convenience of its small size and lightweight build with the ability to accelerate the stem cell harvesting process– but that isn’t all. The GCell has been designed to be an entirely enclosed system– this is important, as it means that samples that are run through the GCell will remain in a sterile environment, which preserves the viability of samples and ensures positive outcomes for patients.
The GCell combines a grinder, a filter, and a photoactivation device, and is a turnkey solution that can take a physician from harvesting a fat sample to administering an injectable regenerative medicine therapy in less than an hour. GCell has been designed to be especially useful for clinics that are just beginning to implement regenerative medicine into their practice, but it’s all inclusive approach to stem cell isolation is what sets it a cut above the rest.
GCell’s Single Session Treatment Protocol
Unlike many other cellular therapies on the market, it is a single-session treatment, which means that there is no need for the patient to come back after his original treatment day has ended. This machine’s portability, small stature, and ability to accelerate the stem cell harvesting process makes it ideal for clinics that are just beginning to implement regenerative medicine into their practices, as it takes much of the rigor out of adipose-derived stem cell harvesting.
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ISSCA Announces Speaker’s List for 7th Annual Symposium
The International Society for Stem Cells Applications has officially announced and published its list of speakers for its 7th Annual Regenerative Medicine Symposium. The seventh event of its kind, it is another effort from the iSSCA to bring together a network of regenerative medicine practitioners from all over the world. At previous events, hundreds of physicians came to share in their knowledge regarding cellular therapies and the patients whose lives they can change, and the aim of this year is no different– of course, as a reunion of medical professionals, several steps will be taken to ensure proper social distancing measures, as well as frequent opportunities for sanitation.
As with previous editions of the event, the topics discussed and speakers involved have been updated and edited in an effort to reflect the changing of time and the rapid evolution of the field of regenerative medicine. That is why this symposium will focus on Cellular Therapies During and After the Pandemic. Coronavirus has changed life as we know it, but the scientific and medical communities have not stopped researching. In fact, cellular therapies have been an invaluable asset in managing the largest pandemic in modern history, due to their implications in treating respiratory failure and managing some of the complications induced by exposure to COVID-19. This has resulted in accelerated pathways for regulatory approval and increased funding for new regenerative medicine-based clinical trials, which will all be discussed in greater depth at the event.
But the Regenerative Medicine Symposium also provides a valuable networking opportunity for physicians in the Latin American community. “Here, people interested in cellular therapy can find everything they need to get on the right path to helping people with regenerative medicine,” Said Benito Novas, VP of Public Relations, ISSCA, “If you’ve done some research yourself, or really have no idea where to start– this would be the place. We’ve got vendors, instructors, and interview panels with several distinguished researchers,”
About ISSCA
The International Society for Stem Cells Applications (ISSCA) is a multidisciplinary community of scientists and physicians, all of whom aspire to treat diseases and lessen human suffering through advances in science, technology, and the practice of regenerative medicine. Incorporated under the Republic of Korea as a non-profit entity, the ISSCA is focused on promoting excellence and standards in the field of regenerative medicine.
ISSCA bridges the gaps between scientists and practitioners in Regenerative Medicine.
Their code of ethics emphasizes principles of morals and ethical conducts.
At ISSCA, their vision is to take a leadership position in promoting excellence and setting standards in the regenerative medicine fields of publication, research, education, training, and certification. ISSCA serves its members through advancements made to the specialty of regenerative medicine. They aim to encourage more physicians to practice regenerative medicine and make it available to benefit patients both nationally and globally.
For more information, please visit us at www.issca.us or send an email to info@stemcellsgroup.com.
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Global Stem Cells Group To Start Training Physicians In Lisbon, Portugal as Early as Sep. 2020
The Global Stem Cells Group has at last finalized discussions to open a The Stem Cell Center Network site in Lisbon, portugal. The Stem Cell Center operates an international network of regenerative medicine practitioners that is dedicated to sharing information with the end goal of bringing cutting-edge regenerative medicine-based treatments to patients suffering from debilitating disease.
The new Portuguese Stem Cell Center will be comprised of a highly-accredited, state of the art clinic/laboratory manned by physicians and scientists with combined decades of experience. It will be another strong foothold in Iberia for the global company, and carries with it full license to use the Group’s proprietary treatment methods and branding designs.
This will be the Global Stem Cell Group’s first permanent location in Portugal, rounding out the company’s presence in Western Europe and the Portuguese-speaking market with the new Lisbon-based partnership. The Stem Cell Center Network continues to roll out new membership opportunities, programs, and events, and our membership has grown steadily year after year– To date, we are present in twenty five countries and five continents.
And to commemorate this partnership the Stem Cell Network has plans to open the clinic in September of 2020, and begin training physicians shortly after. “We’ve wanted to expand into Portugal for a very long time,” Said Benito Novas, Founder and CEO, Global Stem Cells Group, “Now that the world is tentatively opening up, it seemed like a good time to resume teaching physicians– after all, with more people getting sick, it is important for their doctors to have all the tools at their fingertips to help,”
Barring any extenuating circumstances, the Stem Cell Center Network remains scheduled to open in the first week of September, with bookings already being accepted for the Network’s inaugural training at this clinic. With limited availability due to current social distancing efforts, spots are filling up quickly, and prospective applicants are encouraged to sign up soon for the hands-on training course.
To Sign Up Today, Visit us At: www.issca.us
About Global Stem Cells Group
Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. The united efforts of GSCG’s affiliate companies provide medical practitioners with a one-stop hub for stem cell solutions that adhere to the highest medical standards.
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Global Stem Cells Group CEO Benito Novas Confirmed Speaker at 1st Ibero-American Fellowship Program in Regenerative and Functional Medicin
The First International Iber-American University Diploma has been announced to focus on laser therapy, hormone therapy, and wellness, and brings with it over a dozen seasoned instructors. The fellowship program, which spans over multiple weeks, covers a variety of topics with the focus of expanding the professional vision of medical professionals, and furthering knowledge of the applications of lasers in gynecology and cosmetic medicine. Additionally, it will update physicians on the newest techniques developed around the world to improve the quality of life of patients. A variety of protocols will be covered, including office, operating room, and hormone-based procedures.
The Fellowship Program has been certified by Atlantic International University, which is a private university based in Honolulu, Hawaii. Those physicians who complete the fellowship will be asked to demonstrate their knowledge through the use of clinical case studies involving real patients. Additionally, AIU offers students the opportunity to supplement this program with resources in various areas of knowledge, at no extra cost.
Benito Novas, CEO of Global Stem Cells Group, had this to say about the conference: “I am extremely proud and excited to be bringing this conference to physicians around the world. The program has been organized and directed by dear friends of mine, who have put in countless hours to ensure over a dozen physicians from a wide variety of specialties– really, nearly every field of medicine will be represented, and the course has been structured to ensure maximum retention for each and every student of ours,”
As a result, Global Stem Cells Group and the International Society for Stem Cells Application have both officially endorsed the course as a way for a physician to increase his knowledge in subjects ranging from cosmetic surgery, to marketing strategies, to hormone therapy, and everything in between. To learn more about the First International Ibero-American University Diploma, you may send an email to aiu-curso@amgerweb.com.
About Global Stem Cells Group
Global Stem Cells Group (GSCG) is a worldwide network that combines seven major medical corporations, each focused on furthering scientific and technological advancements to lead cutting-edge stem cell development, treatments, and training. The united efforts of GSCG’s affiliate companies provide medical practitioners with a one-stop hub for stem cell solutions that adhere to the highest medical standards.
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